The first weekend of March Madness was as crazy as ever, as the 2021 NCAA tournament looked to award college basketball fans a two-year wait for the event.
There were countless upsets in the early stages. The No. 2 seed fell to Ohio State 15-seed Oral Roberts. Abilene Christian scored in the round of 32 to free Texas’ Hearts two late freebies. Loyola topped No. 1 seed Illinois in the second round of the Chicago tournament.
And, of course, two trends continued for another year. Syracuse earned a spot in the Sweet 16 as a double-seeded seed, while the First Four, one of eight teams at UCLA, also advanced so far.
If you bet on any major upsets like this so far, congratulations! It has been a difficult-to-predict tournament with all the upsets, but the payoff has been huge with choosing the right underdog. And there will be opportunities to earn money by making favorite bets, picking the right sleepers, and making some tricky parlays, which may be more than you think.
What are the best bets for Sweet 16? Sporting News has you covered with some top trends, advice and a pinch to give you a chance at your second weekend as March Madness.
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March Madness for Sweet 16
Below are the early March Madness talks for Sweet 16, including point spreads, money lines, and over-under totals for every game, According to FanDuel Sportsbook.
sport | Spread | money Line | over under |
Oregon State vs. Loyola Chicago | LUC -6.5 | Luke-270 | 125.5 |
Villanova vs Boiler | BAY -6.5 | BAY-270 | 139 |
Oral Roberts vs Arkansas | ARK-11.5 | ARK-620 | 159 |
Syracuse vs Houston | HOU -6 | HOU-260 | 140 |
Cronton vs Gonzaga | GON-11.5 | GON-1000 | 158 |
Florida State vs. Michigan | MICH -3 | Mhh-162 | 145 |
Oregon vs. USC | Usc-1 | USC-118 | 139 |
UCLA vs Alabama | ALA -5.5 | ALA-235 | Is 142.5 |
March Madness best bets for Sweet 16
Loyola Chicago (-6.5) vs. Oregon State
The Beavers have performed well in the Pac-12 tournament and the first doubles round of March Madness, but are likely to come up against Rambilas. Loyola Chicago knocked off the No. 1 seed, and one of the major title favorites in this tournament, Illinois with a dominant defensive performance. The Ramblers allow the fewest points per game in college basketball (56.1) and rank No. 1 in defensive efficiency according to the KPP rankings. Frankly, they are not your average 8 seed and they can easily be given the top five seeds in this tournament with no complaints.
Loyola Chicago will have a chance to continue their run as they can thwart Oregon State’s offensive attack, something that neither Tennessee nor Oklahoma State were able to do. Expect Cameron Krutwig to help them separate the defense and lead Rambilas to a convincing victory.
Syracuse (+6) vs Houston
Death, Kara, and Jim Boehm’s Syracuse squad make Sweet 16 when they are double digit seeds. Those are the things you can count on in the world. Yes, the 11-seeded Orange are in the Sweet 16 and have a potential shot at a final four due to the chaotic nature of the Midwest Region. Dropping Houston will not be an easy task, but one of the Cougars’ best players, Dejon Jereua, is playing through a hip pointer. He may have been better off with extra time to rest, but it was clearly affecting him during a game that Houston almost lost against the Rutgers.
In terms of efficiency, Houston’s seventh-ranked offense could be slightly lower if Jarreau is below 100 percent. This could open the door for Syracuse and his 17th-order offense to set up a troubled bid. At the very least, we are ready to take the points here because the red-hot Buddy Boehm (27.5 points per game in the tournament) should have a chance to pass and finish it within six points.
USC (-1) vs Oregon
Both of these Pac-12 teams performed well in their second round matchup. Oregon lost its first 56 points to win over Luca Garza and the Iowa Hawkeyes. USC demolished Kansas and dealt with them The third worst loss in the history of the Jayhawks program. Which team has a hand in this matchup? This is USC. He has a ton size on his roster, including star player Evan Mobley (7–0), while only one player was 6-6 in at least 10 minutes of play against Oregon Iowa.
Until 6–11 Frank Kepang, an inexperienced fresher who recurs to join the Ducks in the spring, can play a few extra minutes and cause some problems to Moby, it looks like a game where USC Will benefit In addition, USC won in double digits against the Duck in the first year. So, if we only need to take one point to get USC, we’ll take a shot at them.
March Madell is the best benefit for Sweet 16
Creighton vs Gonzaga over 158 and Oral Roberts vs Arkansas OVER 159
What’s in these two games, far and away, is the highest point on this slate, so it makes sense to include them as potential / more at stake. Creighton vs. Gonzaga has all the constructions of another high scoring relationship. Gonzaga has scored at least 82 points in nine of his last 10 matches played and leads the NCAA at an average of 92.3. Crayton has none of the pockets, as they average 76.5 points per game, tied for 44th-most in the NCAA. They only average 67.5 points in the two March Madness games, but perhaps they will come out with some extra firepower in this one. Even if they don’t, Gonzaga is always a threat to score 100, so they can make up for any deficiencies on Blue Jay’s side.
For the Oral Roberts vs. Arkansas game, Over is appealing on paper. Both teams rank in the top 40 NCAA-wide in terms of speed and Arkansas should be able to score a few points over the 15 seed Golden Eagles. Having said that, Oral Roberts should also be able to score. They are 11th in the NCAA in 3-point percentages this year at 38.5 percent, yet during this tournament, they have hit only 31.6 percent of their deep shots. There is bound to be some regression to the mean, so they can be for a good 3-point shooting day. Of course, a fast paced game would mean more points.
Betting overs in college is always a risky proposition, especially when they are both at this high. But for a 5: 5 mark, it could be worth a shot in these two competitions.
Loyola Chicago (-6.5) and Boiler (-6)
We have already discussed why the Rumblers are a good pick, but there is a simple reason why tying them with beers seems like a good option.
So far this year, the boilers have beaten both opponents of their NCAA tournament by 13+ points. They score the third-most in the NCAA with 83.8 points and allow only 65.8 points per game in a season. Obviously, some references have to apply, as they have won some big non-conference victories, but they have beaten six ranked teams by six or more points this year. Villanova is certainly a strong team and has played well to start the tournament, but without their star player, Colin Gillespai, they may eventually struggle to keep things together. It can come against the Baylor team which is coming into form at the right time.
Getting +264 juice on two medium-sized favorites seems like a good combination here. So, we’ll take it and expect Baylor’s offense to show up in a big way and let Loyola out of Chicago’s defense balls again.
Syracuse (Moneyline) and Alabama (-5.5)
There is an offset-based Parel that can pay big. As mentioned above, Syracuse should have a chance to keep it near Houston, if Jarreau is not at 100 percent, and Boeheim has gone on fire during the tournament. They have a chance to win, and while point spread is undoubtedly safe, it may be worthwhile to risk for a big money bet.
To take advantage of a possible Syracuse bet, you can combine them with one of the preferred points, which is a solid point spread. In this case, Alabama is preferred. The Crimson Tide have won both of their tournament games by 13+ points and while UCLA is on a three-game winning streak, they have yet to play as good an offense as Alabama. The Bruins will likely see the stretch of their wins over Michigan State, BYU and Abilene Christian, so getting ‘Bama’ for 5.5 points seems like a solid value.
On this condition, we will get +501 juice. This is by no means an easy bet to win, but if it comes out, it will definitely be worth our time.
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